대학원공지
[세미나] 뇌과학 세미나 안내
2021-04-15 582

 

일시:  2021년 4월 19일 (월요일) 오후 1시

발표연자:  Jaekyung Kim, PhD
University of California-San Francisco, San Francisco, USA

 

제목: Roles of Sleep Oscillations in Memory Consolidation Versus Forgetting of Motor Learning
초록: Sleep has been implicated in both memory consolidation and forgetting of experiences.
However, it is unclear what governs the balance between memory consolidation and forgetting.
We tested how activity-dependent processing during sleep might differentially regulate these two
processes (Kim et al., Cell, 2019). This study made an important discovery about the underlying
neural basis of offline memory processing by introducing two types of slow waves (slow-
oscillations/SO vs. delta-waves) and fill a gap between the leading theories; the “active
systems consolidation” and the “synaptic homeostasis hypothesis” (SHY). My presentation will
show that SO and delta-waves have dissociable and competing roles in memory consolidation versus
forgetting during NREM sleep using real-time closed-loop optogenetic methods. Based on these
findings, we examined precisely how activity-dependent processing during sleep is affected by
stroke and how to optimally recruit such processing via a pharmacological reduction of tonic
GABA to benefit motor memory consolidation and thereby, rehabilitation. The last part of my
presentation will show how the sleep-dependent processes in the multi-regional areas of brain are
linked to the long-term motor learning (i.e., reach-to-grasp task) in rats.